Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons

Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons

Abstract RET (REarranged during Transfection) is a receptor tyrosine kinase that transduces various external stimuli into biological functions, such as survival and differentiation, in neurons. In the current study, we developed an optogenetic tool for modulating RET signaling, termed optoRET, combi...

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Bibliographic Details
Main Authors: Bobae Hyeon, Heeyoung Lee, Nury Kim, Won Do Heo
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Brain
Subjects:
Optogenetics
RET
GDNF
PHR
Neuron
Signaling
Online Access:https://doi.org/10.1186/s13041-023-01046-6

Internet

https://doi.org/10.1186/s13041-023-01046-6

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