A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals

A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals

In this study we present an inducible biosensor model for the Estrogen Receptor Beta (ERβ), GFP-ERβ:PRL-HeLa, a single-cell-based high throughput (HT) in vitro assay that allows direct visualization and measurement of GFP-tagged ERβ binding to ER-specific DNA response elements (EREs), ERβ-induced ch...

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Bibliographic Details
Main Authors: Derek A. Abbott, Maureen G. Mancini, Michael J. Bolt, Adam T. Szafran, Kaley A. Neugebauer, Fabio Stossi, Daniel A. Gorelick, Michael A. Mancini
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Estrogen receptor beta
High content analysis
High throughput microscopy
Endocrine disruptors
Zebrafish
Estrogen receptor alpha
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023103276

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http://www.sciencedirect.com/science/article/pii/S2405844023103276

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