Hippocampus of the APPNL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis

Hippocampus of the APPNL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis

Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy of cortical and hippocampal brain structures are classic hallmarks of Alzheimer’s disease (AD). Prominent macroscopic disturbances to the cytoarchitecture of the AD brain occur alongside changes in the mechanical propertie...

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Bibliographic Details
Main Authors: Chloe M. Hall, Soufian Lasli, Bianca Serwinski, Boris Djordjevic, Graham K. Sheridan, Emad Moeendarbary
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
atomic force microscopy
brain tissue elasticity
healthy aging
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1212212/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1212212/full

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