Liver-targeting MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan

Liver-targeting MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan

Commercial gadolinium (Gd)-based contrast agents (GBCAs) play important role in clinical diagnostic of hepatocellular carcinoma, but their diagnostic efficacy remained improved. As small molecules, the imaging contrast and window of GBCAs is limited by low liver targeting and retention. Herein, we d...

Full description

Bibliographic Details
Main Authors: Li Xu, Zhanying Ren, Guolin Li, Danni Xu, Jiaqian Miao, Jingxuan Ju, Xuan Mo, Xianghui Wang, Hongping Deng, Min Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
gadolinium (Gd)-based MRI contrast agents
liver-targeting
imaging contrast
galactose functionized o-carboxymethyl chitosan
biocompatibility
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1134665/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1134665/full

Similar Items