Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear

Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear

Muscle atrophy arises from a multiplicity of physio-pathological situations and has very detrimental consequences for the whole body. Although knowledge of muscle atrophy mechanisms keeps growing, there is still no proven treatment to date. This study aimed at identifying new drivers for muscle atro...

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Bibliographic Details
Main Authors: Laura Cussonneau, Christian Boyer, Charlotte Brun, Christiane Deval, Emmanuelle Loizon, Emmanuelle Meugnier, Elise Gueret, Emeric Dubois, Daniel Taillandier, Cécile Polge, Daniel Béchet, Guillemette Gauquelin-Koch, Alina L. Evans, Jon M. Arnemo, Jon E. Swenson, Stéphane Blanc, Chantal Simon, Etienne Lefai, Fabrice Bertile, Lydie Combaret
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
brown bear hibernation
mouse unloading
muscle atrophy
physical inactivity
RNA sequencing
TGF-β/BMP signaling
Online Access:https://www.mdpi.com/2073-4409/10/8/1873

Internet

https://www.mdpi.com/2073-4409/10/8/1873

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