Re-formulating Gehan’s design as a flexible two-stage single-arm trial
Abstract Background Gehan’s two-stage design was historically the design of choice for phase II oncology trials. One of the reasons it is less frequently used today is that it does not allow for a formal test of treatment efficacy, and therefore does not control conventional type-I and type-II error...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-01-01
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| Series: | BMC Medical Research Methodology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12874-019-0659-2 |