Cytotoxic N-Methylpretrichodermamide B Reveals Anticancer Activity and Inhibits P-Glycoprotein in Drug-Resistant Prostate Cancer Cells

Cytotoxic N-Methylpretrichodermamide B Reveals Anticancer Activity and Inhibits P-Glycoprotein in Drug-Resistant Prostate Cancer Cells

N-methylpretrichodermamide B (NB) is a biologically active epidithiodiketopiperazine isolated from several strains of the algae-derived fungus <i>Penicillium</i> sp. Recently, we reported the first data on its activity in human cancer cells lines in vitro. Here, we investigated the activ...

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Bibliographic Details
Main Authors: Sergey A. Dyshlovoy, Tobias Busenbender, Jessica Hauschild, Elena V. Girich, Malte Kriegs, Konstantin Hoffer, Markus Graefen, Anton N. Yurchenko, Carsten Bokemeyer, Gunhild von Amsberg
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Marine Drugs
Subjects:
marine fungi
N-methylpretrichodermamide B
prostate cancer
cytotoxic activity
drug-resistance
p-glycoprotein
Online Access:https://www.mdpi.com/1660-3397/20/10/597

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https://www.mdpi.com/1660-3397/20/10/597

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