DRP1 Inhibition Rescues Mitochondrial Integrity and Excessive Apoptosis in CS-A Disease Cell Models

DRP1 Inhibition Rescues Mitochondrial Integrity and Excessive Apoptosis in CS-A Disease Cell Models

Cockayne syndrome group A (CS-A) is a rare recessive progeroid disorder characterized by sun sensitivity and neurodevelopmental abnormalities. Cells derived from CS-A patients present as pathological hallmarks excessive oxidative stress, mitochondrial fragmentation and apoptosis associated with hype...

Full description

Bibliographic Details
Main Authors: Barbara Pascucci, Francesca Spadaro, Donatella Pietraforte, Chiara De Nuccio, Sergio Visentin, Paola Giglio, Eugenia Dogliotti, Mariarosaria D’Errico
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
cockayne syndrome
mitochondrial dysfunction
apoptosis
MDIVI-1
Online Access:https://www.mdpi.com/1422-0067/22/13/7123

Internet

https://www.mdpi.com/1422-0067/22/13/7123

Similar Items