The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection

The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection

The RTS,S/AS01 vaccine provides partial protection against Plasmodium falciparum infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associated with RTS,S/AS01 efficacy against controlled h...

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書誌詳細
主要な著者: Ying Du, Ethan G. Thompson, Julius Muller, Joseph Valvo, Jackie Braun, Smitha Shankar, Robert A. van den Berg, Erik Jongert, Drew Dover, Jerald Sadoff, Jenny Hendriks, Malcolm J. Gardner, W. Ripley Ballou, Jason A. Regules, Robbert van der Most, Alan Aderem, Christian F. Ockenhouse, Adrian V. Hill, Ulrike Wille-Reece, Daniel E. Zak
フォーマット: 論文
言語:English
出版事項: Frontiers Media S.A. 2020-04-01
シリーズ:Frontiers in Immunology
主題:
malaria vaccines
clinical immunology
vaccine correlates
human challenge
systems vaccinology
interferon response
オンライン･アクセス:https://www.frontiersin.org/article/10.3389/fimmu.2020.00669/full

インターネット

https://www.frontiersin.org/article/10.3389/fimmu.2020.00669/full

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