Discovery of novel benzylquinazoline molecules as p97/VCP inhibitors

Discovery of novel benzylquinazoline molecules as p97/VCP inhibitors

Introduction: Protein p97 is an extensively investigated AAA ATPase with various cellular activities, including cell cycle control, ubiquitin–proteasome system, autophagy, and NF-κB activation.Method: In this study, we designed, synthesized and evaluated eight novel DBeQanalogs as potential p97 inhi...

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Bibliographic Details
Main Authors: Xiaoyi Zhang, Lingna Jiang, Yixin Li, Qiqi Feng, Xiulin Sun, Yaonan Wang, Ming Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
p97/VCP inhibitor
ATPase activity
organic synthesis
antiproliferative and anti-tumor activity
ubiquitin–proteasome system
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1209060/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1209060/full

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