Synthesis, In-Vitro Antibacterial, Antifungal, and Molecular Modeling of Potent Anti-Microbial Agents with a Combined Pyrazole and Thiophene Pharmacophore

Synthesis, In-Vitro Antibacterial, Antifungal, and Molecular Modeling of Potent Anti-Microbial Agents with a Combined Pyrazole and Thiophene Pharmacophore

Ethyl 5-acetyl-4-methyl-2-(phenylamino)thiophene-3-carboxylate (2) and there derivatives 3a–c, 4, 6a–c and 9a–f were synthesized. The structure of compound 2 was deduced by 1H-NMR, 13C-NMR, FT-IR, MS, microanalysis, and single-crystal X-ray crystallography. The compound crystallized in the monoclini...

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Bibliographic Details
Main Authors: Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, Salem S. Al-Showiman, Assem Barakat, Hazem A. Ghabbour, Wolfgang Frey
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
thiophene
enaminone
[2+3] cycloaddition
anti-microbial activity
molecular modeling
Online Access:http://www.mdpi.com/1420-3049/20/5/8712

Internet

http://www.mdpi.com/1420-3049/20/5/8712

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