Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest of the cell cycle and apoptosis. Genistein down-regulated the levels of cyclin A and cyclin B1, but up-regulat...

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Bibliographic Details
Main Authors: Cheol Park, Hee-Jae Cha, Hyesook Lee, Hyun Hwang-Bo, Seon Yeong Ji, Min Yeong Kim, Su Hyun Hong, Jin-Woo Jeong, Min Ho Han, Sung Hyun Choi, Cheng-Yun Jin, Gi-Young Kim, Yung Hyun Choi
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Antioxidants
Subjects:
genistein
G2/M arrest
apoptosis
ROS
PI3K/Akt
Online Access:https://www.mdpi.com/2076-3921/8/9/327

Internet

https://www.mdpi.com/2076-3921/8/9/327

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