Delineating gene–environment effects using virtual twins of patients treated with clozapine

Abstract Studies that focus on individual covariates, while ignoring their interactions, may not be adequate for model‐informed precision dosing (MIPD) in any given patient. Genetic variations that influence protein synthesis should be studied in conjunction with environmental covariates, such as ci...

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Bibliographic Details
Main Authors: Sam Mostafa, Thomas M. Polasek, Chad Bousman, Amin Rostami‐Hodjegan, Leslie J. Sheffield, Ian Everall, Christos Pantelis, Carl M. J. Kirkpatrick
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12886