Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

Abstract Background The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in APOE4 carriers. Methods Patients aged 50–74 years with cerebrospinal fluid (CSF) biomarker-confirmed AD, were recruited to c...

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Bibliographic Details
Main Authors: Roger M. Lane, Taher Darreh-Shori, Candice Junge, Dan Li, Qingqing Yang, Amanda L. Edwards, Danielle L. Graham, Katrina Moore, Catherine J. Mummery
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Neurology
Subjects:
Butyrylcholinesterase
Cholinergic
Glial activation
Innate immune
Apolipoprotein E
Amyloid
Online Access:https://doi.org/10.1186/s12883-024-03611-5

Internet

https://doi.org/10.1186/s12883-024-03611-5

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