The Rod-Shaped ATG2A-WIPI4 Complex Tethers Membranes In Vitro

The autophagosome precursor membrane, termed the isolation membrane or phagophore , emerges adjacent to a phosphatidylinositol 3-phosphate (PI3P)-enriched transient subdomain of the endoplasmic reticulum called the omegasome , thereafter expanding to engulf cytoplasmic content. Uncovering the molecu...

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Bibliographic Details
Main Authors: Takanori Otomo, Saikat Chowdhury, Gabriel C. Lander
Format: Article
Language:English
Published: SAGE Publishing 2018-12-01
Series:Contact
Online Access:https://doi.org/10.1177/2515256418819936