Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice

Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice

Dnm2fl/fl Pf4-Cre (Dnm2Plt–/–) mice lacking the endocytic GTPase dynamin 2 (DNM2) in platelets and megakaryocytes (MKs) develop hallmarks of myelofibrosis. At the cellular level, the tyrosine kinase JAK2 is constitutively active but decreased in expression in Dnm2Plt–/– platelets. Additionally, Dnm2...

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Bibliographic Details
Main Authors: Nathan Eaton, Emily K. Boyd, Ratnashree Biswas, Melissa M. Lee-Sundlov, Theresa A. Dlugi, Haley E. Ramsey, Shikan Zheng, Robert T. Burns, Martha C. Sola-Visner, Karin M. Hoffmeister, Hervé Falet
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
mpl
dnm2
megakaryopoeiesis
erythropoiesis
hematopoiesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.959806/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.959806/full

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