TRPM2-mediated Ca2+ signaling as a potential therapeutic target in cancer treatment: an updated review of its role in survival and proliferation of cancer cells

TRPM2-mediated Ca2+ signaling as a potential therapeutic target in cancer treatment: an updated review of its role in survival and proliferation of cancer cells

Abstract The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in surviving the cell as well as defending the adaptability of various cell groups during and after oxidative stress. I...

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Bibliographic Details
Main Authors: Eunus S. Ali, Brototi Chakrabarty, Sarker Ramproshad, Banani Mondal, Neloy Kundu, Chandan Sarkar, Javad Sharifi-Rad, Daniela Calina, William C. Cho
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell Communication and Signaling
Subjects:
TRPM2 ion channel
Ca2+ signaling
Oxidative stress
Cancer
Therapeutic target
Online Access:https://doi.org/10.1186/s12964-023-01149-6

Internet

https://doi.org/10.1186/s12964-023-01149-6

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