CXCL1-CXCR1/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy

CXCL1-CXCR1/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy

CXCL1, a functional murine orthologue of the human chemokine CXCL8 (IL-8), and its CXCR1 and CXCR2 receptors were investigated in a murine model of acquired epilepsy developing following status epilepticus (SE) induced by intra-amygdala kainate. CXCL8 and its receptors were also studied in human tem...

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Bibliographic Details
Main Authors: Rossella Di Sapia, Till S. Zimmer, Valentina Kebede, Silvia Balosso, Teresa Ravizza, Diletta Sorrentino, Manuel Alejandro Montano Castillo, Luca Porcu, Franca Cattani, Anna Ruocco, Eleonora Aronica, Marcello Allegretti, Laura Brandolini, Annamaria Vezzani
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Neurobiology of Disease
Subjects:
Chemokine
Glia
Neuroinflammation
Neurodegeneration
Reparixin
Status epilepticus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121002175

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http://www.sciencedirect.com/science/article/pii/S0969996121002175

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