P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death.

P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death.

Extracellular adenosine triphosphate (ATP) functions as a novel danger signal that boosts antitumor immunity and can also directly kill tumor cells. We have previously reported that chronic exposure of tumor cells to ATP provokes P2X7-mediated tumor cell death, by as yet incompletely defined molecul...

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Bibliographic Details
Main Authors: Shu Bian, Xiaofeng Sun, Aiping Bai, Chunqing Zhang, Linglin Li, Keiichi Enjyoji, Wolfgang G Junger, Simon C Robson, Yan Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3615040?pdf=render

Internet

http://europepmc.org/articles/PMC3615040?pdf=render

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