Intestinal Epithelial Cells Adapt to Chronic Inflammation through Partial Genetic Reprogramming

Intestinal Epithelial Cells Adapt to Chronic Inflammation through Partial Genetic Reprogramming

Reactive oxygen species (ROS) are considered to be the main drivers of inflammatory bowel disease. We investigated whether this permanent insult compels intestinal stem cells to develop strategies to dampen the deleterious effects of ROS. As an adverse effect, this adaptation process may increase th...

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Bibliographic Details
Main Authors: Guillaume Collin, Jean-Philippe Foy, Nicolas Aznar, Nicolas Rama, Anne Wierinckx, Pierre Saintigny, Alain Puisieux, Stéphane Ansieau
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
adaptation to chronic-inflammation-associated oxidative stress
intestinal cell reprogramming
ZEB transcription factors
inflammatory bowel disease progression
Online Access:https://www.mdpi.com/2072-6694/15/3/973

Internet

https://www.mdpi.com/2072-6694/15/3/973

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