Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda

Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda

Abstract Background The global burden of sepsis is concentrated in sub-Saharan Africa, where severe infections disproportionately affect young, HIV-infected adults and high-burden pathogens are unique. In this context, poor understanding of sepsis immunopathology represents a crucial barrier to deve...

Full description

Bibliographic Details
Main Authors: Matthew J. Cummings, Barnabas Bakamutumaho, Adam Price, Nicholas Owor, John Kayiwa, Joyce Namulondo, Timothy Byaruhanga, Moses Muwanga, Christopher Nsereko, Stephen Sameroff, Rafal Tokarz, Wai Wong, Shivang S. Shah, Michelle H. Larsen, W. Ian Lipkin, Julius J. Lutwama, Max R. O’Donnell
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Critical Care
Subjects:
Sepsis
Biomarkers
Tuberculosis
High-throughput nucleotide sequencing
Uganda
Africa
Online Access:https://doi.org/10.1186/s13054-022-03907-3

Internet

https://doi.org/10.1186/s13054-022-03907-3

Similar Items