Investigation of the Antihypertrophic and Antifibrotic Effects of Losartan in a Rat Model of Radiation-Induced Heart Disease

Investigation of the Antihypertrophic and Antifibrotic Effects of Losartan in a Rat Model of Radiation-Induced Heart Disease

Radiation-induced heart disease (RIHD) is a potential late side-effect of thoracic radiotherapy resulting in left ventricular hypertrophy (LVH) and fibrosis due to a complex pathomechanism leading to heart failure. Angiotensin-II receptor blockers (ARBs), including losartan, are frequently used to c...

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Bibliographic Details
Main Authors: Mónika Gabriella Kovács, Zsuzsanna Z. A. Kovács, Zoltán Varga, Gergő Szűcs, Marah Freiwan, Katalin Farkas, Bence Kővári, Gábor Cserni, András Kriston, Ferenc Kovács, Péter Horváth, Imre Földesi, Tamás Csont, Zsuzsanna Kahán, Márta Sárközy
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
onco-cardiology
radiation-induced heart disease
diastolic dysfunction
left ventricular hypertrophy
fibrosis
heart failure
Online Access:https://www.mdpi.com/1422-0067/22/23/12963

Internet

https://www.mdpi.com/1422-0067/22/23/12963

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