PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

Mechanisms driving the initiation of brain folding are incompletely understood. We have previously characterized mouse models recapitulating human PIK3CA-related brain overgrowth, epilepsy, dysplastic gyrification and hydrocephalus (Roy et al., 2015). Using the same, highly regulatable brain-specifi...

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Bibliographic Details
Main Authors: Achira Roy, Rory M Murphy, Mei Deng, James W MacDonald, Theo K Bammler, Kimberly A Aldinger, Ian A Glass, Kathleen J Millen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
PI3K
cortical gyrification
critical period
hydrocephalus
Yap
Online Access:https://elifesciences.org/articles/45961

Internet

https://elifesciences.org/articles/45961

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