Computational pharmacokinetic analysis on some newly designed 2-anilinopyrimidine derivative compounds as anti-triple-negative breast cancer drug compounds

Computational pharmacokinetic analysis on some newly designed 2-anilinopyrimidine derivative compounds as anti-triple-negative breast cancer drug compounds

Abstract Introduction Worldwide, cancer of the breast is the most commonly diagnosed disease and the second leading cause of cancer-related mortality amongst women yearly (Miller et al., 2016). Computer-aided drug discovery (CADD) is a fundamental shortcut in drug discovery arena. CADD tools ascerta...

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Bibliographic Details
Main Authors: Hadiza Lawal Abdulrahman, Adamu Uzairu, Sani Uba
Format: Article
Language:English
Published: SpringerOpen 2020-04-01
Series:Bulletin of the National Research Centre
Subjects:
Molecular docking studies
2-anilinopyrimidine
MDA-MB-468 cell line
Thyroid hormone receptor (TRβ1)
Structure-based design
Pharmacokinetic analysis
Online Access:http://link.springer.com/article/10.1186/s42269-020-00321-z

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http://link.springer.com/article/10.1186/s42269-020-00321-z

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