Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice

Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice

Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake-behaving...

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Bibliographic Details
Main Authors: Knut Sindre Åbjørsbråten, Gry HE Syverstad Skaaraas, Céline Cunen, Daniel M Bjørnstad, Kristin M Gullestad Binder, Laura Bojarskaite, Vidar Jensen, Lars NG Nilsson, Shreyas B Rao, Wannan Tang, Gudmund Horn Hermansen, Erlend A Nagelhus, Ole Petter Ottersen, Reidun Torp, Rune Enger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
Alzheimer's disease
calcium imaging
norepinephrine
astrocytes
Online Access:https://elifesciences.org/articles/75055

Internet

https://elifesciences.org/articles/75055

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