Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

Abstract Background Alzheimer Disease (AD) and cerebral amyloid angiopathy (CAA) are both characterized by amyloid-β (Aβ) accumulation in the brain, although Aβ deposits mostly in the brain parenchyma in AD and in the cerebrovasculature in CAA. The presence of CAA can exacerbate clinical outcomes of...

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Bibliographic Details
Main Authors: Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E. Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R. Gonzales, Michal Kipnis, David M. Holtzman
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Neurodegeneration
Subjects:
APOE
Cerebral amyloid angiopathy
Cerebrovasculature
Astrocyte
Amyloid-β
Online Access:https://doi.org/10.1186/s13024-023-00610-x

Internet

https://doi.org/10.1186/s13024-023-00610-x

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