Derivation and Preclinical Characterization of CYT-303, a Novel NKp46-NK Cell Engager Targeting GPC3

Derivation and Preclinical Characterization of CYT-303, a Novel NKp46-NK Cell Engager Targeting GPC3

Glypican-3 (GPC3) is an oncofetal antigen that is highly expressed in multiple solid tumors, including hepatocellular carcinoma, and is barely expressed in adult normal tissues except the placenta. NKp46 activation receptor is expressed in all-natural killer (NK) cells, including tumor-infiltrating...

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Bibliographic Details
Main Authors: Antonio Arulanandam, Liang Lin, Hao-Ming Chang, Martine Cerutti, Sylvie Choblet, Peng Gao, Armin Rath, Armand Bensussan, Jean Kadouche, Daniel Teper, Ofer Mandelboim, Wei Li
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
natural killer cells
NK engager
bispecific antibody
NKp46
GPC3
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2073-4409/12/7/996

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https://www.mdpi.com/2073-4409/12/7/996

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