A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

The increase in activity of the two-pore potassium-leak channel Kcnk5b maintains allometric juvenile growth of adult zebrafish appendages. However, it remains unknown how this channel maintains allometric growth and how its bioelectric activity is regulated to scale these anatomical structures. We s...

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Bibliographic Details
Main Authors: Chao Yi, Tim WGM Spitters, Ezz Al-Din Ahmed Al-Far, Sen Wang, TianLong Xiong, Simian Cai, Xin Yan, Kaomei Guan, Michael Wagner, Ali El-Armouche, Christopher L Antos
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
potassium channel
electrophysiology
tissue scaling
proportional growth
transcription
calcineurin
Online Access:https://elifesciences.org/articles/60691

Internet

https://elifesciences.org/articles/60691

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