Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction

Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction

Obesity mediates most of its direct medical sequelae through the development of insulin resistance (IR). The cellular effects of insulin occur through two main postreceptor pathways that are the phosphatidylinositol 3-kinase (PI3-K) and the mitogen-activated protein kinase (MAP-K) pathways. Obesity-...

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Bibliographic Details
Main Authors: Thomas M. Barber, Ioannis Kyrou, Harpal S. Randeva, Martin O. Weickert
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
insulin resistance
obesity
metabolic dysfunction
cognitive dysfunction
Online Access:https://www.mdpi.com/1422-0067/22/2/546

Internet

https://www.mdpi.com/1422-0067/22/2/546

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