Interaction of Angiotensin II AT1 Receptors with Purinergic P2X Receptors in Regulating Renal Afferent Arterioles in Angiotensin II-Dependent Hypertension

Interaction of Angiotensin II AT1 Receptors with Purinergic P2X Receptors in Regulating Renal Afferent Arterioles in Angiotensin II-Dependent Hypertension

In angiotensin II (Ang II)-dependent hypertension, Ang II activates angiotensin II type 1 receptors (AT1R) on renal vascular smooth muscle cells, leading to renal vasoconstriction with eventual glomerular and tubular injury and interstitial inflammation. While afferent arteriolar vasoconstriction is...

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Bibliographic Details
Main Authors: Supaporn Kulthinee, Adis Tasanarong, Martha Franco, Luis Gabriel Navar
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
hypertension
P2X receptors
AT1 receptors
afferent arteriole
angiotensin II infusions
Online Access:https://www.mdpi.com/1422-0067/24/14/11413

Internet

https://www.mdpi.com/1422-0067/24/14/11413

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