Mutant p53K120R expression enables a partial capacity to modulate metabolism

Mutant p53K120R expression enables a partial capacity to modulate metabolism

The TP53 tumor suppressor gene is one of the most studied gene in virtue of its ability to prevent cancer development by regulating apoptosis, cell cycle arrest, DNA repair, autophagy and senescence. Furthermore, the modulation of metabolism by P53 is fundamental for tumor suppressor activity. Studi...

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Bibliographic Details
Main Authors: Paola Monti, Silvia Ravera, Andrea Speciale, Irena Velkova, Giorgia Foggetti, Paolo Degan, Gilberto Fronza, Paola Menichini
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
p53
energy metabolism
K120R mutation
antioxidant response
lipid peroxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.974662/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.974662/full

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