Saffron effects on liver enzymes, antioxidant capacity, insulin, inflammation and genes expression of lipolysis and lipogenesis in a rat model of non-alcoholic fatty liver disease
Summary: Background and aim: According to increasing attention to the protective effects of saffron in liver disease and increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the present study aimed to investigate the mechanism effects of saffron consumption on treatment of NAFLD in a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Clinical Nutrition Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268523000736 |
| _version_ | 1797347074311716864 |
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| author | Naheed Aryaeian Roya Alipour Sahar Jafari Karegar Mansoreh Soleimani AghaFatemeh Hosseini Azita Hekmatdoost |
| author_facet | Naheed Aryaeian Roya Alipour Sahar Jafari Karegar Mansoreh Soleimani AghaFatemeh Hosseini Azita Hekmatdoost |
| author_sort | Naheed Aryaeian |
| collection | DOAJ |
| description | Summary: Background and aim: According to increasing attention to the protective effects of saffron in liver disease and increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the present study aimed to investigate the mechanism effects of saffron consumption on treatment of NAFLD in a rat model. Materials and Methods: In this study 24 male Sprague-Dawley rats were studied for 13 weeks. Rats were divided in 4 groups, including group 1 that was fed HFHS+ 250 mg/kg S, group 2 that was fed HFHS+ 125 mg/kg S, group 3 that was fed HFHS, and group 4 that was fed chow diet. Results: Saffron consumption in HFHS+ 250 mg/kg S group and in HFHS + 150 mg/kg S group led to a significant reduction in ALT, AST, blood glucose, insulin, and significant elevation in TAC versus HFHS group. Saffron consumption in HFHS+250, 150 mg/Kg S caused a significant reduction in TG and significant elevation in HDL serum levels. The difference between HFHS+250 mg/kg S and HFHS for PPARα gene expression was significant (p=0.01). SREBP 1-c gene expression reduction among groups was significant and there was a significant difference between HFHS+250 mg/kg S and HFHS (p=0.02 and 0.05, respectively). DGAT2 gene expression was decreased significantly among groups, and HFHS+125 mg/kg S and HFHS+250 mg/kg S versus to HFHS (p=0.05). Conclusions: This study showed that consumption of Saffron could treat NAFLD in Rats at least partially through modulation in gene expression of PPARα, SREBP 1-c, and DGAT2, liver enzymes, glycemic indices and TAC. |
| first_indexed | 2024-03-08T11:42:29Z |
| format | Article |
| id | doaj.art-7351d4988e3a48418ed156af48817fc0 |
| institution | Directory Open Access Journal |
| issn | 2667-2685 |
| language | English |
| last_indexed | 2024-03-08T11:42:29Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj.art-7351d4988e3a48418ed156af48817fc02024-01-25T05:23:52ZengElsevierClinical Nutrition Open Science2667-26852024-02-015395107Saffron effects on liver enzymes, antioxidant capacity, insulin, inflammation and genes expression of lipolysis and lipogenesis in a rat model of non-alcoholic fatty liver diseaseNaheed Aryaeian0Roya Alipour1Sahar Jafari Karegar2Mansoreh Soleimani3AghaFatemeh Hosseini4Azita Hekmatdoost5Department of Nutrition Sciences, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Corresponding author. Department of Nutrition Sciences, School of Public Health, Iran University of Medical Sciences, Tehran, IR Iran. Tel.: +98 9123093353; fax: +98 86704570.Department of Nutrition Sciences, School of Public Health, Iran University of Medical Sciences, Tehran, IranDepartment of Nutrition Sciences, School of Public Health, Iran University of Medical Sciences, Tehran, IranDepartment of Histology and Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Statistics, School of Public Health, Iran University of Medical Sciences, Tehran, IranDepartment of Clinical Nutrition & Dietetics, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IranSummary: Background and aim: According to increasing attention to the protective effects of saffron in liver disease and increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the present study aimed to investigate the mechanism effects of saffron consumption on treatment of NAFLD in a rat model. Materials and Methods: In this study 24 male Sprague-Dawley rats were studied for 13 weeks. Rats were divided in 4 groups, including group 1 that was fed HFHS+ 250 mg/kg S, group 2 that was fed HFHS+ 125 mg/kg S, group 3 that was fed HFHS, and group 4 that was fed chow diet. Results: Saffron consumption in HFHS+ 250 mg/kg S group and in HFHS + 150 mg/kg S group led to a significant reduction in ALT, AST, blood glucose, insulin, and significant elevation in TAC versus HFHS group. Saffron consumption in HFHS+250, 150 mg/Kg S caused a significant reduction in TG and significant elevation in HDL serum levels. The difference between HFHS+250 mg/kg S and HFHS for PPARα gene expression was significant (p=0.01). SREBP 1-c gene expression reduction among groups was significant and there was a significant difference between HFHS+250 mg/kg S and HFHS (p=0.02 and 0.05, respectively). DGAT2 gene expression was decreased significantly among groups, and HFHS+125 mg/kg S and HFHS+250 mg/kg S versus to HFHS (p=0.05). Conclusions: This study showed that consumption of Saffron could treat NAFLD in Rats at least partially through modulation in gene expression of PPARα, SREBP 1-c, and DGAT2, liver enzymes, glycemic indices and TAC.http://www.sciencedirect.com/science/article/pii/S2667268523000736Nonalcoholic fatty liver diseaseSaffronLiver enzymesPPARαSREBP 1-c |
| spellingShingle | Naheed Aryaeian Roya Alipour Sahar Jafari Karegar Mansoreh Soleimani AghaFatemeh Hosseini Azita Hekmatdoost Saffron effects on liver enzymes, antioxidant capacity, insulin, inflammation and genes expression of lipolysis and lipogenesis in a rat model of non-alcoholic fatty liver disease Clinical Nutrition Open Science Nonalcoholic fatty liver disease Saffron Liver enzymes PPARα SREBP 1-c |
| title | Saffron effects on liver enzymes, antioxidant capacity, insulin, inflammation and genes expression of lipolysis and lipogenesis in a rat model of non-alcoholic fatty liver disease |
| title_full | Saffron effects on liver enzymes, antioxidant capacity, insulin, inflammation and genes expression of lipolysis and lipogenesis in a rat model of non-alcoholic fatty liver disease |
| title_fullStr | Saffron effects on liver enzymes, antioxidant capacity, insulin, inflammation and genes expression of lipolysis and lipogenesis in a rat model of non-alcoholic fatty liver disease |
| title_full_unstemmed | Saffron effects on liver enzymes, antioxidant capacity, insulin, inflammation and genes expression of lipolysis and lipogenesis in a rat model of non-alcoholic fatty liver disease |
| title_short | Saffron effects on liver enzymes, antioxidant capacity, insulin, inflammation and genes expression of lipolysis and lipogenesis in a rat model of non-alcoholic fatty liver disease |
| title_sort | saffron effects on liver enzymes antioxidant capacity insulin inflammation and genes expression of lipolysis and lipogenesis in a rat model of non alcoholic fatty liver disease |
| topic | Nonalcoholic fatty liver disease Saffron Liver enzymes PPARα SREBP 1-c |
| url | http://www.sciencedirect.com/science/article/pii/S2667268523000736 |
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