Different Transcriptomic Response to T. cruzi Infection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy

Different Transcriptomic Response to T. cruzi Infection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy

Chagas disease is a tropical zoonosis caused by Trypanosoma cruzi. After infection, the host present an acute phase, usually asymptomatic, in which an extensive parasite proliferation and intense innate immune activity occurs, followed by a chronic phase, characterized by low parasitemia and develop...

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Bibliographic Details
Main Authors: Theo G. M. Oliveira, Gabriela Venturini, Juliana M. Alvim, Larissa L. Feijó, Carla L. Dinardo, Ester C. Sabino, Jonathan G. Seidman, Christine E. Seidman, Jose E. Krieger, Alexandre C. Pereira
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
chagas disease
chagas cardiomyopathy
iPSC (induced pluripotent stem cell)
Trypanosoma cruzi (T. cruzi)
RNA-Seq
cardiomyocytes (CMs)
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.904747/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.904747/full

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