Rotenone and Its Derivative, Rotenoisin A, Induce Neurodegeneration Differentially in SH-SY5Y Cells

Rotenone and Its Derivative, Rotenoisin A, Induce Neurodegeneration Differentially in SH-SY5Y Cells

Rotenone (ROT), the most significant rotenoid, which has shown anticancer activity, has also been reported to be toxic to normal cells, inducing Parkinson’s disease (PD)-like neuronal loss with aggregation of α-synuclein (α-syn). To reduce the adverse effects of ROT, its derivative, rotenoisin A (RO...

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Bibliographic Details
Main Authors: Mahesh Ramalingam, Sujeong Jang, Seongryul Kim, Hyoungwoo Bai, Gyeonghan Jeong, Byeong C. Kim, Han-Seong Jeong
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Biomedicines
Subjects:
α-synuclein
neurotoxicity
autophagy
Akt
caspases
Online Access:https://www.mdpi.com/2227-9059/12/8/1703

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https://www.mdpi.com/2227-9059/12/8/1703

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