Metformin hydrochloride improves hepatic glucolipid metabolism in diabetes progression through SIRT5-mediated ECHA desuccinylation

Metformin hydrochloride improves hepatic glucolipid metabolism in diabetes progression through SIRT5-mediated ECHA desuccinylation

Abstract The management of hyperglycemia and lipid metabolism is pivotal for the treatment of type 2 diabetes mellitus (T2DM). Metformin hydrochloride (DMBG) remains the most widely prescribed medication for this condition. This study aimed to elucidate the effects and underlying mechanisms by which...

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Bibliographic Details
Main Authors: Liang Tang, Qing Sun, Jinling Luo, Suying Peng
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Metformin hydrochloride
Hyperglycemia
Lipid metabolism
Desuccinylation
ECHA
Online Access:https://doi.org/10.1038/s41598-025-92716-z

Internet

https://doi.org/10.1038/s41598-025-92716-z

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