An Efficient Solvent-Free Synthesis of 2-Hydroxy-2-(trifluoromethyl)-2H-chromenes Using Silica-Immobilized L-Proline

An Efficient Solvent-Free Synthesis of 2-Hydroxy-2-(trifluoromethyl)-2H-chromenes Using Silica-Immobilized L-Proline

An efficient synthesis of 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates was carried out under solvent-free conditions in an oven or microwave oven via the Knoevenagel condensation of salicylaldehydes with ethyl trifluoroacetoacetate followed by intramolecular cyclization in the presence o...

Full description

Bibliographic Details
Main Authors: Ya Gao, Lixia Xie, Sufang Fan, Guoyu Yang, Caixia Wang, Cuilian Xu
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Molecules
Subjects:
solvent-free
2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates
synthesis
Knoevenagel condensation
silica-immobilized L-proline
Online Access:http://www.mdpi.com/1420-3049/18/10/11964

Internet

http://www.mdpi.com/1420-3049/18/10/11964

Similar Items