Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells

Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells

Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that inhib...

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Bibliographic Details
Main Authors: Chutamas Thepmalee, Aussara Panya, Jatuporn Sujjitjoon, Nunghathai Sawasdee, Naravat Poungvarin, Mutita Junking, Pa-Thai Yenchitsomanus
Format: Article
Language:English
Published: Taylor & Francis Group 2020-10-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
self-differentiated dendritic cells
immunosuppressive cytokines
tgf-β receptor
il-10 receptor
cholangiocarcinoma
cellular immunotherapy
Online Access:http://dx.doi.org/10.1080/21645515.2019.1701913

Internet

http://dx.doi.org/10.1080/21645515.2019.1701913

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