Assembling the anaerobic gamma-butyrobetaine to TMA metabolic pathway in Escherichia fergusonii and confirming its role in TMA production from dietary L-carnitine in murine models

Assembling the anaerobic gamma-butyrobetaine to TMA metabolic pathway in Escherichia fergusonii and confirming its role in TMA production from dietary L-carnitine in murine models

ABSTRACT Trimethylamine-N-oxide (TMAO) is a major pro-atherogenic and pro-thrombotic metaorganismal molecule produced through the initial conversion of the dietary L-carnitine and other precursors into trimethylamine (TMA). We recently identified a dual-microbe anaerobic pathway for the metabolism o...

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Bibliographic Details
Main Authors: Mohammed Dwidar, Jennifer A. Buffa, Zeneng Wang, Akeem Santos, Aaron N. Tittle, Xiaoming Fu, Adeline M. Hajjar, Joseph A. DiDonato, Stanley L. Hazen
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
TMA
TMAO
L-carnitine
Emergencia timonensis
atherosclerosis
cardiovascular disease
Online Access:https://journals.asm.org/doi/10.1128/mbio.00937-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00937-23

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