Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters
Combining in vitro experiments and physical modeling reveals that three-dimensional clusters form when cellular contractile forces induce a hole in a flat sheet of smooth muscle cells, a process that can be modeled as the brittle fracture of a viscoelastic material.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04578-8 |