Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters
Combining in vitro experiments and physical modeling reveals that three-dimensional clusters form when cellular contractile forces induce a hole in a flat sheet of smooth muscle cells, a process that can be modeled as the brittle fracture of a viscoelastic material.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04578-8 |
| _version_ | 1797863808358678528 |
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| author | Xiuyu Wang David Gonzalez-Rodriguez Thomas Vourc’h Pascal Silberzan Abdul I. Barakat |
| author_facet | Xiuyu Wang David Gonzalez-Rodriguez Thomas Vourc’h Pascal Silberzan Abdul I. Barakat |
| author_sort | Xiuyu Wang |
| collection | DOAJ |
| description | Combining in vitro experiments and physical modeling reveals that three-dimensional clusters form when cellular contractile forces induce a hole in a flat sheet of smooth muscle cells, a process that can be modeled as the brittle fracture of a viscoelastic material. |
| first_indexed | 2024-04-09T22:42:40Z |
| format | Article |
| id | doaj.art-7364522746844f2c98cc44ff6b0dd585 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-09T22:42:40Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-7364522746844f2c98cc44ff6b0dd5852023-03-22T12:05:11ZengNature PortfolioCommunications Biology2399-36422023-03-016111010.1038/s42003-023-04578-8Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clustersXiuyu Wang0David Gonzalez-Rodriguez1Thomas Vourc’h2Pascal Silberzan3Abdul I. Barakat4LadHyX, CNRS, Ecole Polytechnique, Institut Polytechnique de ParisUniversité de LorraineLaboratoire PhysicoChimie Curie, Institut Curie, PSL Research UniversityLaboratoire PhysicoChimie Curie, Institut Curie, PSL Research UniversityLadHyX, CNRS, Ecole Polytechnique, Institut Polytechnique de ParisCombining in vitro experiments and physical modeling reveals that three-dimensional clusters form when cellular contractile forces induce a hole in a flat sheet of smooth muscle cells, a process that can be modeled as the brittle fracture of a viscoelastic material.https://doi.org/10.1038/s42003-023-04578-8 |
| spellingShingle | Xiuyu Wang David Gonzalez-Rodriguez Thomas Vourc’h Pascal Silberzan Abdul I. Barakat Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters Communications Biology |
| title | Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters |
| title_full | Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters |
| title_fullStr | Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters |
| title_full_unstemmed | Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters |
| title_short | Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters |
| title_sort | contractility induced self organization of smooth muscle cells from multilayer cell sheets to dynamic three dimensional clusters |
| url | https://doi.org/10.1038/s42003-023-04578-8 |
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