Disease predisposition of human leukocyte antigen class II genes influences the gut microbiota composition in patients with primary biliary cholangitis

Disease predisposition of human leukocyte antigen class II genes influences the gut microbiota composition in patients with primary biliary cholangitis

BackgroundThe human leukocyte antigen (HLA) susceptibility gene is the main genetic risk factor for primary biliary cholangitis (PBC). The prognosis of patients with PBC is linked to gut microbiota dysbiosis. However, whether the HLA alleles are associated with the gut microbiota distribution and di...

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Main Authors: Chun-Yang Huang, Hai-Ping Zhang, Wei-Jia Han, Dan-Tong Zhao, Hui-Yu Liao, Yin-Xue Ma, Bin Xu, Li-Juan Li, Ying Han, Xiu-Hong Liu, Qi Wang, Jin-Li Lou, Xiao-Dan Zhang, Juan Zhao, Wen-Juan Li, Yan-Min Liu, Hui-Ping Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
primary biliary cholangitis
human leukocyte antigen
gut microbiota
susceptibility gene
bioinformatic analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.984697/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.984697/full

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