Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers

Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers

Abstract Background Recently in Japan, six workers at a chemical plant that manufactures resins developed interstitial lung diseases after being involved in loading and packing cross-linked water-soluble acrylic acid polymers (CWAAPs). The present study focused on assessing lung damage in rats cause...

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Bibliographic Details
Main Authors: Shotaro Yamano, Tomoki Takeda, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, Yoichiro Kobashi, Kenzo Okamoto, Takumi Kishimoto, Yumi Umeda
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Respiratory Research
Subjects:
Cross-linked water-soluble acrylic acid polymer (CWAAP)
Workplace-relevant inhalation exposure
Intratracheal instillation
Rat
Transforming growth factor
Pulmonary disease
Online Access:https://doi.org/10.1186/s12931-023-02355-z

Internet

https://doi.org/10.1186/s12931-023-02355-z

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