Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression

Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression

The design of chimeric antigen receptors (CAR) significantly enhances the antitumor efficacy of T cells. Although some CAR-T products have been approved by FDA in treating hematological tumors, adoptive immune therapy still faces many difficulties and challenges in the treatment of solid tumors. In...

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Bibliographic Details
Main Authors: Wei Jiang, Guosheng Gu, Yumin Zhang, Yushuai Song, Ming Shi, Gang Wang, Huizhong Li, Tingting Tao, Jianhua Qin, Xianliang Li, Hongtao Jia, Feng Jiao, Weidong Xu, Xiaoyi Huang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Pharmacological Research
Subjects:
NKT
CAR-T
Chimeric antigen receptor
Mesothelin
Cellular immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823002980

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http://www.sciencedirect.com/science/article/pii/S1043661823002980

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