Regulation of Hepatocyte Nuclear Factor 4α Attenuated Lipotoxicity but Increased Bile Acid Toxicity in Non-Alcoholic Fatty Liver Disease

Regulation of Hepatocyte Nuclear Factor 4α Attenuated Lipotoxicity but Increased Bile Acid Toxicity in Non-Alcoholic Fatty Liver Disease

Hepatocyte nuclear factor 4 alpha (HNF4α) is a key master transcriptional factor for hepatic fat and bile acid metabolic pathways. We aimed to investigate the role of HNF4α in non-alcoholic fatty liver disease (NAFLD). The role of HNF4α was evaluated in free fatty acid–induced lipotoxicity and cheno...

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Bibliographic Details
Main Authors: Yoon Jin Roh, Yun Kim, Jae Sun Lee, Ju Hee Oh, Seung Min Lee, Eileen Laurel Yoon, Sung Ryol Lee, Dae Won Jun
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Life
Subjects:
hepatocyte nuclear factor 4 alpha
non-alcoholic fatty liver disease
lipotoxicity
bile acid toxicity
steatohepatitis
Online Access:https://www.mdpi.com/2075-1729/12/11/1682

Internet

https://www.mdpi.com/2075-1729/12/11/1682

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