Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer’s disease in vitro and in vivo

Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer’s disease in vitro and in vivo

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-β in neurons, which is a key step in senile plaque formation. Therefore, restoring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new...

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Bibliographic Details
Main Authors: Zhimin Long, Chuanhua Ge, Yueyang Zhao, Yuanjie Liu, Qinghua Zeng, Qing Tang, Zhifang Dong, Guiqiong He
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-09-01
Series:Neural Regeneration Research
Subjects:
alzheimer’s disease
amyloid-β
app/ps1 mice
autophagy
cognitive impairment
histone deacetylase 6
lysosomal acidification
microtubule acetylation
valproic acid
v-atpase
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01633

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https://journals.lww.com/10.4103/NRR.NRR-D-23-01633

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