The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson’s disease mouse models

The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson’s disease mouse models

Abstract Background Neuroinflammation plays a pivotal role in the pathogenesis of Parkinson’s disease (PD). Thus, the development of agents that can control neuroinflammation has been suggested as a promising therapeutic strategy for PD. In the present study, we investigated whether the phosphodiest...

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Bibliographic Details
Main Authors: Yu-Young Lee, Jin-Sun Park, Yea-Hyun Leem, Jung-Eun Park, Do-Yeon Kim, Youn-Hee Choi, Eun-Mi Park, Jihee Lee Kang, Hee-Sun Kim
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease
Neuroinflammation
Neuroprotection
Microglia
PDE10 inhibitor
Papaverine
Online Access:https://doi.org/10.1186/s12974-019-1649-3

Internet

https://doi.org/10.1186/s12974-019-1649-3

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