Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres in the h...

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Main Authors: Vicky Wang-Wei Tsai, Laurence Macia, Christine Feinle-Bisset, Rakesh Manandhar, Arne Astrup, Anne Raben, Janne Kunchel Lorenzen, Peter T Schmidt, Fredrik Wiklund, Nancy L Pedersen, Lesley Campbell, Adamandia Kriketos, Aimin Xu, Zhou Pengcheng, Weiping Jia, Paul M G Curmi, Christopher N Angstmann, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Christopher P Marquis, Yasmin Husaini, Christoph Beglinger, Shu Lin, Herbert Herzog, David A Brown, Amanda Sainsbury, Samuel N Breit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4514813?pdf=render

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http://europepmc.org/articles/PMC4514813?pdf=render

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