1-Pyrroline-5-carboxylate inhibit T cell glycolysis in prostate cancer microenvironment by SHP1/PKM2/LDHB axis

1-Pyrroline-5-carboxylate inhibit T cell glycolysis in prostate cancer microenvironment by SHP1/PKM2/LDHB axis

Abstract Background Our previous studies demonstrated that 1-Pyrroline-5-carboxylate (P5C) released by prostate cancer cells inhibits T cell proliferation and function by increasing SHP1 expression. We designed this study to further explore the influence of P5C on T cell metabolism, and produced an...

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Bibliographic Details
Main Authors: Lei Chang, Guohao Li, Shan Jiang, Jie Li, Jin Yang, Kavita Shah, Le Zhou, Hanrui Song, Leyuan Deng, Zhiguo Luo, Yonglian Guo, Yutao Yan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell Communication and Signaling
Subjects:
P5C
T cell
Prostate cancer
SHP1
Glycolysis
Online Access:https://doi.org/10.1186/s12964-024-01493-1

Internet

https://doi.org/10.1186/s12964-024-01493-1

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