Discovering the mechanism of action of drugs with a sparse explainable networkResearch in context

Summary: Background: Although Deep Neural Networks (DDNs) have been successful in predicting the efficacy of cancer drugs, the lack of explainability in their decision-making process is a significant challenge. Previous research proposed mimicking the Gene Ontology structure to allow for interpreta...

Full description

Bibliographic Details
Main Authors: Katyna Sada Del Real, Angel Rubio
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642300333X