Chromosome 17 abnormalities and mutation of the TP53 gene: correlation between cytogenetics, flow cytometry and molecular analysis in three cases of chronic myeloid leukemia

Chromosome 17 abnormalities and mutation of the TP53 gene: correlation between cytogenetics, flow cytometry and molecular analysis in three cases of chronic myeloid leukemia

chronic myeloid leukemia (CML) have been described. This chromosomal region contains the tumor suppressor gene TP53 that may be an important factor in the evolution of this disease. In this study, we used flow cytometry and western blotting to assess p53 protein expression and single stranded confor...

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Bibliographic Details
Main Authors: Luize Otero, Geraldo Barroso Cavalcanti Júnior, Claudete Esteves Klumb, Marcos Antonio Mauricio Scheiner, Eliane Pereira Simões Magluta, Teresa de Souza Fernandez, Maria Luiza Macedo Silva, Virgínia Pires, Gabriela Vasconcelos Andrade, Raquel Ciuvalschi Maia, Daniel Tabak
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2005-03-01
Series:Genetics and Molecular Biology
Subjects:
chronic myeloid leukemia
chromosome 17
TP53 gene
p53 protein
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100007

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100007

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